This is a pretty broad topic, with a ton of viable solutions. Here's one set of breadcrumbs that should work:
Ktor, Exposed, DataFrames, Compose (if you need a UI)
DataFrames is an official library that will handle excel file I/O
Ktor is the backend framework
Exposed is the ORM for interacting with your database
I recommend checking into those three (four if you include compose) libraries, and maybe trying a tutorial or similar. After that, you'll probably be able to answer this question, or at least ask some more specific clarifying follow-up questions.
Good luck!