My project has recently decided it hates Instant Run for its android component. It seemed to be working fine with coroutines + ktor + serialization, but when I added SQLDelight I had to make some changes (including upgrading to Gradle 5.1.1) which seem to have broken the crap out of instant run. Has anyone else run into this issue? Any thoughts on things which might be causing this?

Instant run usually breaks at some point. I'm not sure there's a good way to fix it.

Probably best to just disable instant run anyway. Its being replaced by "Apply Changes" in AS 3.5

try Android Studio 3.5..Instant Run was so terrible, they had to rename it in 3.5 so people would try it again 😉

Just to be clear, its more than just a rename. Its a complete re-write from the ground up